Medical - Surgical Nursing Journal

Published by: Kowsar

Effect of Isotonic Exercise on the Frequency of Muscle Cramps in Hemodialysis Patients: A Clinical Trial

Mahdi Poornazari ORCID 1 , Mostafa Roshanzadeh ORCID 2 , Somayeh Mohammadi ORCID 1 , Ali Tajabadi ORCID 3 , Khadijeh Dehghani ORCID 4 , * and Sara Parsa 5
Authors Information
1 Nursing Faculty of Brojen, Shahr-e-Kord, Iran
2 Shahid Beheshti Medical Ethics and Law Center, Tehran, Iran
3 Paramedical Faculty, Sabzevar University of Medical Sciences, Sabzevar, Iran
4 Department of Nursing, Nursing and Midwifery Faculty, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5 Islamic Azad University of Najafabad, Isfahan, Iran
Article information
  • Medical - Surgical Nursing Journal: February 28, 2019, 8 (1); e85770
  • Published Online: March 9, 2019
  • Article Type: Research Article
  • Received: October 26, 2018
  • Revised: January 16, 2019
  • Accepted: March 3, 2019
  • DOI: 10.5812/msnj.85770

To Cite: Poornazari M, Roshanzadeh M , Mohammadi S, Tajabadi A, Dehghani K, et al. Effect of Isotonic Exercise on the Frequency of Muscle Cramps in Hemodialysis Patients: A Clinical Trial, Med Surg Nurs J. 2019 ; 8(1):e85770. doi: 10.5812/msnj.85770.

Copyright © 2019, Medical - Surgical Nursing Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Vahed Parast H, Ravanipour M. [Assessing the adequacy of dialysis in patients undergoing hemodialysis in hemodialysis center in Boshehr city]. Sci J Hamadan Nurs Midwifery Fac. 2008;16(2):50-60. Persian.
  • 2. Hadian B, Anbari K, Heidari R. [Epidemiologic study of end stage renal disease and related risk factors in patients under hemodialysis in Lorestan province]. Yafte. 2015;16(3):44-53. Persian.
  • 3. Allen RE, Kirby KA. Nocturnal leg cramps. Am Fam Physician. 2012;86(4):350-5. [PubMed: 22963024].
  • 4. Khatua CR, Panigrahi S, Mishra D, Pradhan S, Sahu SK, Barik RK, et al. Acute kidney injury at admission is a better predictor of mortality than its persistence at 48 h in patients with acute-on-chronic liver failure. J Clin Transl Hepatol. 2018;6(4):396-401. doi: 10.14218/JCTH.2018.00035. [PubMed: 30637217]. [PubMed Central: PMC6328732].
  • 5. Nonoyama ML, Brooks D, Ponikvar A, Jassal SV, Kontos P, Devins GM, et al. Exercise program to enhance physical performance and quality of life of older hemodialysis patients: A feasibility study. Int Urol Nephrol. 2010;42(4):1125-30. doi: 10.1007/s11255-010-9718-7. [PubMed: 20213292]. [PubMed Central: PMC3252390].
  • 6. Galain AI, Dapueto JJ, Alvarez R, Gadola L. Prevalence of symptoms and symptom clusters of patients on dialysis in uruguay. Value Health Reg Issues. 2019;20:28-35. doi: 10.1016/j.vhri.2018.10.003. [PubMed: 30639978].
  • 7. Yesil S, Karsli B, Kayacan N, Suleymanlar G, Ersoy F. [Pain evaluation in patients with chronical renal failure undergoing hemodialysis]. Agri. 2015;27(4):197-204. Turkish. doi: 10.5505/agri.2015.44712. [PubMed: 26860493].
  • 8. Wang JS, Chiang JH, Hsu HJ. Lower risk of musculoskeletal pain among patients with end-stage renal disease treated by hemodialysis: A frequency-matched retrospective cohort study. Medicine (Baltimore). 2018;97(33). e11935. doi: 10.1097/MD.0000000000011935. [PubMed: 30113496]. [PubMed Central: PMC6112929].
  • 9. Tadayon Far MA, Khosrowgerdi H, Amadani M, Tajabadi A, Tabarayi Y. [Comparison of promethazine and morphine to control pain of appendectomy surgery: A randomized clinical trial]. Bimonthl Sabzevar Univ Med Sci. 2015;22(4):589-95. Persian.
  • 10. Khosrojerdi H, Tajabadi A, Amadani M, Akrami R, Tadayonfar M. The effect of isometric exercise on pain severity and muscle strength of patients with lower limb fractures: A randomized clinical trial study. Med Surg Nurs J. 2018;7(1). e68104. doi: 10.5812/msnj.68104.
  • 11. Durand PY, Nicco C, Serteyn D, Attaf D, Edeas M. Microbiota quality and mitochondrial activity link with occurrence of muscle cramps in hemodialysis patients using citrate dialysate: A pilot study. Blood Purif. 2018;46(4):301-8. doi: 10.1159/000490612. [PubMed: 30048977].
  • 12. McDougall GJ. Research review: The effect of acupressure with massage on fatigue and depression in patients with end-stage renal disease. Geriatr Nurs. 2005;26(3):164-5. doi: 10.1016/j.gerinurse.2005.03.008. [PubMed: 15973344].
  • 13. Jansen PH, Gabreels FJ, van Engelen BG. Diagnosis and differential diagnosis of muscle cramps: A clinical approach. J Clin Neuromuscul Dis. 2002;4(2):89-94. doi: 10.1097/00131402-200212000-00008. [PubMed: 19078696].
  • 14. Heiss R, Hotfiel T, Kellermann M, May MS, Wuest W, Janka R, et al. Effect of compression garments on the development of edema and soreness in delayed-onset muscle soreness (DOMS). J Sports Sci Med. 2018;17(3):392-401. [PubMed: 30116112]. [PubMed Central: PMC6090402].
  • 15. Baggetta R, D'Arrigo G, Torino C, ElHafeez SA, Manfredini F, Mallamaci F, et al. Effect of a home based, low intensity, physical exercise program in older adults dialysis patients: A secondary analysis of the EXCITE trial. BMC Geriatr. 2018;18(1):248. doi: 10.1186/s12877-018-0938-5. [PubMed: 30342464]. [PubMed Central: PMC6196029].
  • 16. Esgalhado M, Stockler-Pinto MB, de Franca Cardozo LF, Costa C, Barboza JE, Mafra D. Effect of acute intradialytic strength physical exercise on oxidative stress and inflammatory responses in hemodialysis patients. Kidney Res Clin Pract. 2015;34(1):35-40. doi: 10.1016/j.krcp.2015.02.004. [PubMed: 26484017]. [PubMed Central: PMC4570601].
  • 17. Kim MS, Cho KS, Woo H, Kim JH. Effects of hand massage on anxiety in cataract surgery using local anesthesia. J Cataract Refract Surg. 2001;27(6):884-90. doi: 10.1016/S0886-3350(00)00730-6. [PubMed: 11408136].
  • 18. Takhreem M. The effectiveness of intradialytic exercise prescription on quality of life in patients with chronic kidney disease. Medscape J Med. 2008;10(10):226. [PubMed: 19099020]. [PubMed Central: PMC2605133].
  • 19. Henrique DM, Reboredo Mde M, Chaoubah A, Paula RB. [Aerobic exercise improves physical capacity in patients under chronic hemodialysis]. Arq Bras Cardiol. 2010;94(6):823-8. Portuguese. doi: 10.1590/S0066-782X2010005000043. [PubMed: 20428710].
  • 20. Riahi Z, Esfarjani F, Marandi M, Bayat A, Kalani N. [Regular exercise and physical performance impact on quality Dyalyzf muscle atrophy in hemodialysis patients during dialysis]. J Shahrekord Univ Med sci. 2011;14(5):63-73. Persian.
  • 21. Zamanzade WE. The effect of exercise on quality of life in hemodialysis patients. J Army Univ Med Sci Tabriz. 2008;30(1):55-1.
  • 22. Cheema BS, O'Sullivan AJ, Chan M, Patwardhan A, Kelly J, Gillin A, et al. Progressive resistance training during hemodialysis: Rationale and method of a randomized-controlled trial. Hemodial Int. 2006;10(3):303-10. doi: 10.1111/j.1542-4758.2006.00112.x. [PubMed: 16805893].
  • 23. Yaghobi M, Mohammadi E, Ahmadi F. [Effect of isometric isotonic sports pack on muscle cramps in hemodialysis patients]. Sci J Kurdistan Univ Med Sci. 2007;2(44):53-60. Persian.
  • 24. Hadian Jazi Z, Aliasgharpour M. Effect of walking on pain from muscle cramps in haemodialysis patients internal. Sport Med J. 2012;13(4):161-9.
  • 25. Ozdemir G, Ovayolu N, Ovayolu O. The effect of reflexology applied on haemodialysis patients with fatigue, pain and cramps. Int J Nurs Pract. 2013;19(3):265-73. doi: 10.1111/ijn.12066. [PubMed: 23730858].
  • 26. Abe M, Okada K, Soma M. Mineral metabolic abnormalities and mortality in dialysis patients. Nutrients. 2013;5(3):1002-23. doi: 10.3390/nu5031002. [PubMed: 23525083]. [PubMed Central: PMC3705332].
  • 27. Mustata S, Groeneveld S, Davidson W, Ford G, Kiland K, Manns B. Effects of exercise training on physical impairment, arterial stiffness and health-related quality of life in patients with chronic kidney disease: a pilot study. Int Urol Nephrol. 2011;43(4):1133-41. doi: 10.1007/s11255-010-9823-7. [PubMed: 20842429].
  • 28. Giannaki CD, Sakkas GK, Karatzaferi C, Hadjigeorgiou GM, Lavdas E, Kyriakides T, et al. Effect of exercise training and dopamine agonists in patients with uremic restless legs syndrome: A six-month randomized, partially double-blind, placebo-controlled comparative study. BMC Nephrol. 2013;14:194. doi: 10.1186/1471-2369-14-194. [PubMed: 24024727]. [PubMed Central: PMC3847208].
  • 29. Parsons TL, Toffelmire EB, King-VanVlack CE. Exercise training during hemodialysis improves dialysis efficacy and physical performance. Arch Phys Med Rehabil. 2006;87(5):680-7. doi: 10.1016/j.apmr.2005.12.044. [PubMed: 16635631].
  • 30. Bennett PN, Breugelmans L, Chan D, Calo M, Ockerby C. A combined strength and balance exercise program to decrease falls risk in dialysis patients: A feasibility study. J Exerc Physiol. 2012;15(4):26-39.
  • 31. Bennett PN, Breugelmans L, Barnard R, Agius M, Chan D, Fraser D, et al. Sustaining a hemodialysis exercise program: A review. Semin Dial. 2010;23(1):62-73. doi: 10.1111/j.1525-139X.2009.00652.x. [PubMed: 20331819].
  • 32. Smart N, Steele M. Exercise training in haemodialysis patients: A systematic review and meta-analysis. Nephrology (Carlton). 2011;16(7):626-32. doi: 10.1111/j.1440-1797.2011.01471.x. [PubMed: 21557787].
  • 33. Mortazavi M, Vahdatpour B, Ghasempour A, Taheri D, Shahidi S, Moeinzadeh F, et al. Aerobic exercise improves signs of restless leg syndrome in end stage renal disease patients suffering chronic hemodialysis. ScientificWorldJournal. 2013;2013:628142. doi: 10.1155/2013/628142. [PubMed: 24307876]. [PubMed Central: PMC3836425].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments